期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 12, 期 7, 页码 2205-2210出版社
WILEY
DOI: 10.1046/j.1460-9568.2000.00106.x
关键词
GABA(A) receptor; glycine receptor; inhibitory synapse; postsynaptic specialization; receptor clustering
gamma-aminobutyric acid type A (GABA(A)) receptors are located at the majority of inhibitory synapses in the mammalian brain. However, the mechanisms by which GABA(A) receptor subunits are targeted to, and clustered in, the postsynaptic membrane are poorly understood. Recent studies have demonstrated that gephyrin, a protein first identified as a component of the glycine receptor (GlyR) complex, is colocalized with several subtypes of GABA(A) receptors and is involved in the stabilization of postsynaptic GABA(A) receptor clusters. Thus, gephyrin functions as a clustering protein for major subtypes of inhibitory ion channel receptors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据