期刊
CHEMOSPHERE
卷 41, 期 1-2, 页码 183-186出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0045-6535(99)00409-9
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The activities of calcium-activated ATPase (Ca2+-ATPase) and calcium-magnesium-activated ATPase (Ca2+-Mg2+ ATPase) in the shell gland, and concentrations of 17 beta-estradiol (E-2) and progesterone in serum were monitored, respectively, from hens orally dosed with tri-o-cresyl phosphate (TOCP) (750 mg/kg). Treated birds were monitored daily for laying and development of delayed neurotoxicity, and activities of Ca2+-ATPase and Ca2+-Mg2+-ATPase were measured at 7 and 10 days after dosing. TOCP-treated birds manifested motor deficit by 7-9 days postdosing, while hens administered vehicle exhibited no signs of delayed neurotoxicity. Ca2+-ATPase and Ca2+-Mg2+-ATPase activities of shell glands from TOCP-dosed hens were not significantly affected (P > 0.05). The serum E-2 concentration was significantly reduced in TOCP-treated hens (P < 0.01); however, progesterone levels were unaffected. (C) 2000 Elsevier Science Ltd. All rights reserved.
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