期刊
CELL AND TISSUE RESEARCH
卷 301, 期 1, 页码 163-171出版社
SPRINGER
DOI: 10.1007/s004410000179
关键词
multiple sclerosis; autoimmune disease; apoptosis; CD95; T cell; therapy
类别
Several recent studies have provided evidence that apoptosis is an important feature in the pathogenesis of multiple sclerosis (MS), an autoimmune disease of the central nervous system. Apoptosis presumably plays a role in the immunoregulation via activation-induced T-cell death (AICD) and in local processes of tissue damage. In this review the dual role of apoptosis in the MS pathogenesis and its relevance regarding therapeutic concepts is discussed.
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