期刊
BIOLOGICAL RESEARCH FOR NURSING
卷 16, 期 4, 页码 448-455出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1099800414522689
关键词
exposome; biobehavioral; telomere
类别
资金
- Epigenetics and Psychoneurologic Symptoms in Women with Breast Cancer [R01 NR012667, 10/01/2010-8/30/2015]
- Center of Excellence in Biobehavioral Approaches to Symptom Management [P30 NR011403, 08/10/09-05/31/14]
A major objective of biobehavioral research is defining the mechanisms that underlie linkages among behavior, biology, health, and disease. The genomic revolution has demonstrated the importance of studying the role of the environment in (epi) genetic mechanisms. The idea that interactions between environment and genetics influence health outcomes is a central concept of the exposome, a measure of environmental exposures throughout a lifetime. Research suggests that telomere length (TL) and biologic factors involved in telomere stability may provide an understanding of the effects of gene-environment interaction on disease risk. Telomeres, thus, have become important biomarkers for aging as well as for stress-related disease. However, incorporating telomeres into biobehavioral research requires consideration of several aspects of the exposome. Internal and external modifiable and nonmodifiable exposures have the potential to influence TL. Future research utilizing the concept of the exposome will provide meaningful findings related to exposure sources as well as dosage and duration across the life span that influence telomere biology and disease occurrence. Such findings can be translated into clinical practice and may provide a basis for personalized disease prevention and treatment approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据