期刊
BIOLOGICAL RESEARCH FOR NURSING
卷 14, 期 1, 页码 98-107出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1099800411398933
关键词
nonsteroidal anti-inflammatory drugs; adverse effects; osteoblasts; MG-63; bone tissue
类别
资金
- BIO277 research group (Junta de Andalucia)
- Department of Nursing of the Health Sciences Faculty of the University of Granada
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs worldwide and serve as treatment of some degenerative inflammatory joint diseases. The aim of the present study was to investigate the influence of different concentrations of three NSAIDs on cell proliferation, differentiation, antigenic profile, and cell cycle in the human MG-63 osteosarcoma cell line, incubated for 24 hr. All NSAIDs had an inhibiting effect on osteoblastic proliferation. Treatments for 24 hr had small but significant effects on the antigenic profile. No treatment altered osteocalcin synthesis. Indomethacin and nimesulide treatments arrested the cell cycle at G(0)/G(1). These results suggest that indomethacin, nimesulide, and diclofenac appear to have no effects on osteocalcin synthesis and a slight effect on the antigenic profile. They may delay bone regeneration due to their inhibiting effect on osteoblast growth. Therefore, these drugs should only be used in situations that do not require rapid bone healing.
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