期刊
BIOLOGICAL RESEARCH
卷 46, 期 3, 页码 243-249出版社
SOC BIOLGIA CHILE
DOI: 10.4067/S0716-97602013000300004
关键词
Axon wrapping; Septins; Myelination; Schwann Cells
类别
资金
- Myelin Repair Foundation Project [MRF0104-DRC004]
- Fondecyt project [1080252]
- Vicerrectoria de Investigacion, Universidad de Chile [ENL11 / 08]
Myelin sheaths present two distinct domains: compacted myelin spirals and flanking non-compacted cytoplasmic channels, where lipid and protein segregation is established by unknown mechanisms. Septins, a conserved family of membrane and cytoskeletal interacting GTPases, form intracellular diffusion barriers during cell division and neurite extension and are expressed in myelinating cells. Septins, particularly septin 7 (Sept7), the central constituent of septin polymers, are associated with the cytoplasmic channels of myelinating cells. Here we show that Schwann cells deprived of Sept7 fail to wrap around axons from dorsal root ganglion neurons and exhibit disorganization of the actin cytoskeleton. Likewise, Sept7 distribution is dependent on microfilament but not microtubule organization.
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