期刊
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
卷 81, 期 1-3, 页码 110-121出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-1838(00)00111-9
关键词
ligand-gated cation channels; synaptic transmission; nervous system; P2X; nicotinic; kainate; NMDA; AMPA; 5-HT3
There is now considerable evidence demonstrating that ligand-gated cation channels (i.e., P2X, nicotinic, kainate, NMDA, AMPA and 5-HT3 receptors). in addition to mediating fast excitatory neurotransmission, may be located presynaptically on nerve terminals in the peripheral and central nervous systems where they function to modulate neurotransmitter release. This modulation can be facilitation, inhibition or both. In this article, we first outline the multiple mechanisms by which activation of presynaptic ligand-gated cation channels can modulate spontaneous and evoked neurotransmitter release, before reviewing in detail published electrophysiological studies of presynaptic P2X, nicotinic, kainate, NMDA, AMPA and 5-HT3 receptors. (C) 2000 Elsevier Science B.V. All rights reserved.
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