期刊
ANALYTICA CHIMICA ACTA
卷 416, 期 1, 页码 87-96出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0003-2670(00)00855-2
关键词
flufenamic acid; mefenamic acid; chemiluminescence; flow injection; cerium(IV); tris(2,2 '-bipyridyl)ruthenium(II); pharmaceutical analysis; biological fluids
A novel chemiluminescent method using flow injection has been investigated for the rapid and sensitive determination of flufenamic and mefenamic acids. The method is based on a tris(2,2'-bipyridyl)ruthenium(III) chemiluminescence reaction. Ru(bipy)(3)(3+) is chemically generated by mixing two streams containing solutions of tris(2,2'-bipyridyl)ruthenium(II) and acidic cerium(IV) sulphate. After selecting the best operating parameters calibration graphs were obtained over the concentration ranges 0.07-6.0 and 0.05-6.0 mu g ml(-1) for flufenamic acid and mefenamic acid, respectively. The Limits of detection (s/n = 3) were 3.6 x 10(-9) M flufenamic acid and 2.1 x 10(-7) M mefenamic acid. The method was successfully applied to the determination of these compounds in pharmaceutical formulations and biological fluids. A proposal for the reaction pathway was given. (C) 2000 Elsevier Science B.V, All rights reserved.
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