期刊
BRAIN RESEARCH
卷 870, 期 1-2, 页码 66-72出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(00)02402-1
关键词
spinal cord trauma; oxidative stress; glutamate release; glucocorticoids; excitotoxicity
资金
- NINDS NIH HHS [NS40015, NS-30248, R01 NS040015] Funding Source: Medline
Rats received a contusion injury to the spinal cord followed by treatment with riluzole (a glutamate release inhibitor, 8 mg/kg), methylprednisolone (MP 30 mg/kg) or both. At 4 h following injury, spinal cords were removed and synaptosomes prepared and examined using five measures of oxidative stress. Riluzole treatment was found to improve mitochondrial function, and enhance glutamate and glucose uptake. As expected, MP treatment was found to reduce lipid peroxidation, but also improved glutamate and glucose uptake. Interestingly, the combination treatment was found to be effective in improving all five measures of oxidative stress. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of oxidative stress events in traumatic spinal cord injury. (C) 2000 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据