A convenient and scaleable procedure for removing the Fmoc group in solution

An improved and simple reagent system was developed to facilitate solution-phase deprotection of Fmoc-protected amines. Catalytic DBU in the presence of an aliphatic or polymer-supported thiol rapidly removed the Fmoc group to provide the amine free base in excellent yields and purity on multi-gram scale. (C) 2000 Elsevier Science Ltd. All rights reserved.