期刊
BIOLOGICAL PSYCHOLOGY
卷 138, 期 -, 页码 27-34出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.biopsycho.2018.08.006
关键词
MAOA gene; Aggression; Inhibitory control; Default mode network
资金
- Natural Science Foundation of China [81471384]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130162110043]
It has been demonstrated, in a long line of research, that the low-activity genotype of the monoamine oxidase A (MAOA) gene is associated with aggression. Previous work has linked impaired response inhibition to aggression, but little is known about how this relates to the purported MAOA-aggression relationship in adolescents. Here, we examined how MAOA genotype influences neural correlates of inhibitory control in 74 healthy male adolescents using a GoStop and a Go/Nogo task while differentiating between action cancelation and action restraint. Carriers of the low-expressing MAOA alleles (MAOA-L) did not show altered brain activation in the prefrontal-subcortical inhibition network relative to carriers of the high-expressing alleles across inhibition conditions. However, they exhibited a more pronounced deactivation during response inhibition in the posterior cingulate cortex (PCC) and precuneus, areas belonging to the default mode network (DMN). Larger DMN suppression in MAOA-L carriers might represent a compensation mechanism for impaired cognitive control.
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