期刊
BIOLOGICAL PSYCHOLOGY
卷 97, 期 -, 页码 1-8出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.biopsycho.2013.12.016
关键词
Insomnia; fMRI; EEG; Resting state; Insula; Salience networks
资金
- Stanford Graduate Research Opportunity Grant
- American Psychological Association Dissertation Research Award
- Norman H. Anderson Research Grant
- National Institute of Mental Health [T32 MH019956]
Insomnia is among the most prevalent and costly of all sleep-related disorders. To characterize the neural mechanisms underlying subjective dysfunction in insomnia, we examined brain activity in 17 female insomniacs and 17 female healthy controls using simultaneous functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) while they were resting and while they were trying to fall asleep. In examining the dynamic regional activity within intrinsic brain networks, we found that, compared with controls, insomniacs had greater involvement of the anterior insula with salience networks, as well as insula BOLD correlation with EEG gamma frequency power during rest in insomniacs. This increased involvement of the anterior insula was associated with negative affect in insomniacs. Aberrant activation of the insula, which integrates temporal and bodily states, in arousal networks may underlie the misperception of sleep quality and subjective distress in insomnia. (C) 2014 Elsevier B.V. All rights reserved.
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