期刊
BIOLOGICAL PSYCHOLOGY
卷 99, 期 -, 页码 150-159出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.biopsycho.2014.03.009
关键词
PTSD; Remitted PTSD; Inflammation; IL-6; sIL-6R; Anticipation
资金
- National Institute on Aging [R21 AG024902-02]
- University of Louisville [50433]
- University of Louisville Hospital Clinical Research Center
This study correlated lifetime PTSD diagnostic status with interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) levels, and tested whether these correlations are sensitive to psychological context. Midlife women attended two research visits where blood was drawn (beginning of visits) and saliva and oral mucosal transudate were collected (beginning and end of visits) to measure IL-6 and sIL-6R. Women were classified as PTSD-/- (past and current symptoms below subsyndromal levels), PTSD+/- (past symptoms at or above subsyndromal levels), or PTSD+/+ (past and current symptoms at or above subsyndromal levels). PTSD+/+ women, compared to the other women, showed more negative emotion at the beginning of the visits, higher salivary IL-6 levels at the beginning versus end of visits, and positive correlations between negative emotion, salivary IL-6, and plasma sIL-6R. Their plasma sIL-6R levels exceeded those of the PTSD+/- women. Overall, IL-6 sensitivity to anticipation and to negative emotions, and higher sIL-6R levels, differentiated persistent versus remitted PTSD. (C) 2014 Elsevier B.V. All rights reserved.
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