期刊
BIOLOGICAL PSYCHOLOGY
卷 97, 期 -, 页码 35-42出版社
ELSEVIER
DOI: 10.1016/j.biopsycho.2014.02.002
关键词
Telomere length; Early life stress; Traumatic experiences; Cellular aging; Biomarker; Aging-related diseases
资金
- Emil Aaltonen Foundation
- Helsinki University Research Funds
- National Doctoral Programme of Psychology
- Academy of Finland
- Ministry of Education
- British Heart Foundation
- Finnish Foundation for Cardiovascular Research
- Finnish Diabetes Research Foundation
- Finnish Medical Society
- Finska Lakaresallskapet
- Samfundet Folkhalsan
- Paivikki and Sakari Sohlberg Foundation
- Juho Vainio Foundation
- Yrjo Jahnsson Foundation
- Signe and Ane Gyllenberg Foundation
- Sigrid Juselius Foundation
- Jalmari and Rauha Ahokas Foundation
- Finnish Foundation for Pediatric Research
- Novo Nordisk Fonden [NNF12OC1016374] Funding Source: researchfish
Early life stress (ELS) poses a risk for mental disorders and aging-related diseases. Accelerated biological aging, reflected in shorter leukocyte telomere length (LTL), may underlie these risks. We examined whether objectively recorded ELS and retrospectively self-reported traumatic experiences across the lifespan are associated with LTL in later adulthood. Of 1486 participants, 215 had been exposed to ELS, namely to temporary separation from both parents in childhood. Participants self-reported emotionally or physically traumatic experiences across the lifespan at a mean age of 63.2 years. LTL was measured using a quantitative PCR method at a mean age of 61.5 years. Separation or self-reported traumatic experiences were not associated with LTL. However, separated participants who self-reported traumatic experiences had shorter LTL. Our results suggest that while ELS or self-reported traumatic experiences are not per se associated with LTL measured decades later, ELS may in combination with self-reported traumatic events be associated with accelerated biological aging. (C) 2014 Elsevier B.V. All rights reserved.
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