期刊
NEUROLOGY
卷 55, 期 1, 页码 134-136出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.55.1.134
关键词
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The epsilon 4 allele of the apolipoprotein E (APOE) gene confers an increased risk for the development of AD. The authors compared longitudinal rates of change in hippocampal volume as a function of APOE genotype in nondemented elderly individuals. Rate of volumetric loss was significantly greater among epsilon 4+ compared with epsilon 4- individuals. These results indicate that individuals positive for the APOE epsilon 4 allele may show a greater rate of hippocampal atrophy than their epsilon 4- counterparts, even in the absence of a diagnosis of AD.
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