期刊
BIOLOGICAL PSYCHOLOGY
卷 96, 期 -, 页码 28-34出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.biopsycho.2013.10.006
关键词
5HTTLPR; Gene x environment interaction; Health; Resources; Susceptibility
资金
- National Institute of Child Health and Human Development [5R01HD030588-16A1]
- National Institute on Drug Abuse [1P30DA027827]
Exposure to cumulative SES risk in childhood may interact with variability at the serotonin transporter linked polymorphic region (5HTTLPR) to alter DNA methylation across interacting sets of proteins. DNA was obtained from 388 African Americans at age 19. Genotype at the 5HTTLPR was determined, and methylation ratios for C-phosphate-G (CpG) residues were assessed. Exposure to cumulative SES risk was determined using repeated parental reports at ages 11-13. At high SES risk, CpG methylation patterns indicated altered cellular stress response in women, but not men, who carried a short allele at the 5HTTLPR. These changes in methylation patterns may lead to increases in mental and physical health risks. No genotype effect emerged for either women or men at low SES risk. Methylation patterns provide guidance in identifying pathways by which genetic susceptibility is transformed into adverse outcomes years later. (C) 2013 Elsevier B.V. All rights reserved.
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