期刊
BIOLOGICAL PSYCHOLOGY
卷 92, 期 1, 页码 2-8出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.biopsycho.2011.12.007
关键词
Generalization; Conditioned fear; Anxiety; Fear learning
资金
- Office of Naval Research [N0014-04-1-005]
- National Science Foundation [0954643]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0954643] Funding Source: National Science Foundation
Recent studies on fear generalization have demonstrated that fear-potentiated startle and skin conductance responses to a conditioned stimulus (CS) generalize to similar stimuli, with the strength of the fear response linked to perceptual similarity to the CS. The aim of the present study was to extend this work by examining neural correlates of fear generalization. An initial experiment (N=8) revealed that insula reactivity tracks the conditioned fear gradient. We then replicated this effect in a larger independent sample (N=25). Activation in the insula, anterior cingulate, right supplementary motor cortex and caudate increased reactivity as generalization stimuli (GS) were more similar to the CS, consistent with participants' overall ratings of perceived shock likelihood and pupillary response to each stimulus. (C) 2012 Published by Elsevier B.V.
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