4.4 Article

Reconsolidation in a human fear conditioning study: A test of extinction as updating mechanism

期刊

BIOLOGICAL PSYCHOLOGY
卷 92, 期 1, 页码 43-50

出版社

ELSEVIER
DOI: 10.1016/j.biopsycho.2011.09.016

关键词

Fear-conditioning; Fear memory; Reconsolidation; Extinction; Anxiety disorders

资金

  1. Netherlands Organization for Scientific Research

向作者/读者索取更多资源

Disrupting reconsolidation seems to be a promising approach to dampen the expression of fear memory. Recently, we demonstrated that disrupting reconsolidation by a pharmacological manipulation specifically targeted the emotional expression of memory (i.e., startle response). Here we test in a human differential fear-conditioning paradigm with fear-relevant stimuli whether the spacing of a single unreinforced retrieval trial relative to extinction learning allows for rewriting the original fear association, thereby preventing the return of fear. In contrast to previous findings reported by Schiller et al. (2010), who used a single-method for indexing fear (skin conductance response) and fear-irrelevant stimuli, we found that extinction learning within the reconsolidation window did not prevent the recovery of fear on multiple indices of conditioned responding (startle response, skin conductance response and US-expectancy). These conflicting results ask for further critical testing given the potential impact on the field of emotional memory and its application to clinical practice. (C) 2011 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据