期刊
JOURNAL OF NEUROSCIENCE
卷 20, 期 14, 页码 5516-5525出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.20-14-05516.2000
关键词
LTD; LTP; eyelid conditioning; Pavlov; timing; simulation; cerebellum
资金
- NIMH NIH HHS [R01 MH057051, R01 MH046904, MH46904, MH57051] Funding Source: Medline
We used large-scale computer simulations of eyelid conditioning to investigate how the cerebellum generates and makes use of temporal information. In the simulations the adaptive timing displayed by conditioned responses is mediated by two factors: (1) different sets of granule cells are active at different times during the conditioned stimulus (CS), and (2) responding is not only amplified at reinforced times but also suppressed at unreinforced times during the CS. These factors predict an unusual pattern of responding after partial removal of the cerebellar cortex that was confirmed using small, electrolytic lesions of cerebellar cortex. These results are consistent with timing mechanisms in the cerebellum that are similar to Pavlov's inhibition of delay hypothesis.
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