期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
卷 1492, 期 2-3, 页码 548-552出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-4781(00)00141-X
关键词
CTP synthetase; nucleotide; tumor cell; Ara-C; resistance; regulation
A full-length cDNA clone encoding an isoform of human CTP synthetase (type II) was isolated. A 1761-nucleotide open reading frame which corresponds to a protein of 586 amino acids with a predicted molecular mass of 65678 Da was identified. The predicted protein sequence showed 74% identity with the translation product of a previously identified human CTP synthetase cDNA clone (type I). The function of the human cDNA encoding type II CTP synthetase was verified by successful complementation of the cytidine-requiring CTP synthetase deficient mutant JF618 of Escherichia coli. The gene encoding type II CTP synthetase has been localized on chromosome Xp22. (C) 2000 Elsevier Science B.V. All rights reserved.
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