期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 107, 期 2, 页码 201-204出版社
ELSEVIER
DOI: 10.1016/S0165-5728(00)00228-9
关键词
autoimmunity; viral infections; chronic inflammation
Viral infections can be responsible for the onset and sustaining of autoimmune processes. We discuss how chronic inflammation associated with viral persistence is the prerequisite for initiation of a multi-step process leading to autoimmunity. Firstly, chronic inflammation may favor the priming of autoreactive T cells that have escaped thymic selection and are specific for self-mimicking viral peptides in the periphery, In addition, viral persistence and inflammation can act synergistically to induce and sustain autoimmunity either unveiling cryptic self-epitopes, or favoring determinant spreading, or activating dendritic cells, or promoting constant priming of new autoreactive T cells, or contributing to the efficient generation of effector cells, or, finally, restimulating memory T lymphocytes. (C) 2000 Elsevier Science B.V. All rights reserved.
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