[GRAPHICS] The Diets-Alder addition of diene 2 with benzoquinone catalyzed by (S)-BINOL-TiCl2 produced cycloadduct 5 in >65% yield and 87% ee. The cycloadduct was transformed into (-)-ibogamine in nine steps (10% overall yield from benzoquinone). A model for the transition state leading to 5 is proposed.
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