Facile synthesis of chiral isopropyl carbinols with high enantiomeric excess via catalytic enantioselective addition of diisopropylzinc to aldehydes

Highly effective syntheses of chiral alkyl and aryl isopropyl carbinols with high enantiomeric excess (94-98% ec) via catalytic enantioselective addition of diisopropylzinc to aldehydes have been developed. (C) 2000 Elsevier Science Ltd. All rights reserved.