期刊
TETRAHEDRON
卷 56, 期 31, 页码 5579-5586出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(00)00408-7
关键词
selenapenams; beta-lactam; selenoketones; azomethine ylid
Using azomethine ylid reactivity available from the beta-lactam-based oxazolidinone 1, selenoketones 6a-e react as 1,3-dipolarophiles to give racemic selenapenams 7a-e in a single step. The cycloaddition sequence proceeds with complete control of regiochemistry and the thermodynamically more stable C(3)/C(5) relationship is observed. The selenothiocarboxylate 9a and the selenocarboxylate 9b also function as effective dipolarophiles, but attempts to convert the resulting cycloadducts 10a and 10b to the corresponding selenapenems were unsuccessful. Other selenium-containing dipolarophiles failed to give characterizable cycloadducts. (C) 2000 Elsevier Science Ltd. All rights reserved.
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