期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1467, 期 1, 页码 198-206出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0005-2736(00)00221-2
关键词
diphytanoyl phosphatidylcholine bilayer; dimyristoyl phosphatidylcholine; X-ray diffraction; phase transition; headgroup energetics; chain energetics
资金
- NIGMS NIH HHS [GM55203] Funding Source: Medline
A comparative study on bilayers of diphytanoyl phosphatidylcholine (DPhPC) and bilayers of dimyristoyl phosphatidylcholine (DMPC) was made by X-ray lamellar diffraction as a function of temperature and the degree of hydration. An order-disorder phase transition of DPhPC reveals an interesting contrast to the standard model of DMPC. Electron density profiles allow us to deduce the conformational changes which occur in the headgroup-glycerol region and in the chain region. The important conclusion is that the lipid headgroup may have different conformational energetics in lipids of different chains. We explain why this is important to protein-membrane interactions. (C) 2000 Elsevier Science B.V. All rights reserved.
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