期刊
INVESTIGATIVE RADIOLOGY
卷 35, 期 8, 页码 479-485出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004424-200008000-00004
关键词
optical imaging; contrast agents; tumor targeting; dye-peptide conjugates
RATIONALE AND OBJECTIVES. TO evaluate the efficacy of a novel tumor receptor-specific small-peptide-near-infrared dye conjugate for tumor detection by optical imaging. METHODS. A novel, near-infrared dye-peptide conjugate was synthesized and evaluated for tumor-targeting efficacy in a well-characterized rat tumor model (CA20948) known to express receptors for the chosen peptide. A simple continuous-wave optical imaging system, consisting of a near-infrared laser diode, a tooled CCD camera, and an interference filter, was used in this study. RESULTS. Tumor retention of two non-tumor-specific dyes, indocyanine green and its derivatized analogue, bis-propanoic acid cyanine dye (cypate), was negligible. In contrast, the receptor-specific peptide-cypate conjugate (cytate) was retained in the CA20948 tumor, with an excellent tumor-to-normal-tissue ratio in the six rats examined, CONCLUSIONS. Optical detection of tumors with a receptor-targeted fluorescent contrast agent has been demonstrated. This result represents a new direction in cancer diagnosis and patient management.
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