期刊
BIOLOGICAL PSYCHIATRY
卷 75, 期 4, 页码 284-291出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2013.07.018
关键词
Autoantibody; encephalitis; encephalopathy; N-methyl-D-aspartate receptor (NMDAR); leucine-rich glioma-inactivated 1 (Lgi1); paraneoplastic; psychosis; schizophrenia; voltage-gated potassium channel complex (VGKC)
资金
- Medical Research Council [MR/J012939/1] Funding Source: Medline
- MRC [MR/J012939/1] Funding Source: UKRI
- Medical Research Council [MR/J012939/1] Funding Source: researchfish
This review concentrates on the evidence for autoantibodies to cell surface synaptic proteins in psychosis and schizophrenia. We and others have recently found antibodies to the N-methyl-D-aspartate receptor in first-episode psychosis. We describe the evidence for pathogenicity and disease-relevance of these antibodies, which builds on the novel field in neuroimmunology of cell surface antibody-associated central nervous system disorders. Relevant autoantibodies in psychosis and schizophrenia are likely to be those directed to cell surface proteins, in which the likelihood of pathogenicity is greater. We discuss the evidence for this from the field of paraneoplastic neurologic syndromes and the discovery of novel cell surface antigen central nervous system autoimmune syndromes.
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