期刊
BIOLOGICAL PSYCHIATRY
卷 73, 期 8, 页码 756-762出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2012.12.002
关键词
Cognitive control; dopamine; individual differences; prefrontal cortex; response inhibition; serotonin; striatum
资金
- Public Health Service [P20-DA022539, P50-MH077248, RL1-MH083270, F31-DA028812, T32-DA024635]
Background: The compulsive and inflexible behaviors that are present in many psychiatric disorders, particularly behavioral addictions and obsessive-compulsive disorder, may be due to neurochemical dysfunction within the circuitry that enables goal-directed behaviors. Experimental removal of serotonin or dopamine within the orbitofrontal cortex or dorsal striatum, respectively, impairs flexible responding in a reversal learning test, suggesting that these neurochemical systems exert important modulatory influences on goal-directed behaviors. Nevertheless, the behavioral impairments present in psychiatric disorders are likely due to subtle neurochemical differences, and it remains unknown whether naturally occurring variation in neurochemical levels associate with individual differences in flexible, reward-directed behaviors. Methods: The current study assessed the ability of 24 individual juvenile monkeys to acquire, retain, and reverse discrimination problems and examined whether nnonoamine levels in the orbitofrontal cortex, caudate nucleus, and putamen could explain variance in behavior. Results: The interaction between dopamine levels in the putamen and serotonin levels in the orbitofrontal cortex explained 61% of the variance in a measure of behavioral flexibility but not measures of associative learning or memory. The interaction mirrored that of a hyperbolic function, with reversal learning performance being poorest in either monkeys with relatively low levels of orbitofrontal serotonin and putamen dopamine or in monkeys with relatively high levels of orbitofrontal serotonin and putamen dopamine levels. Conclusions: These results support the hypothesis that subcortical and cortical neuromodulatory systems interact to guide aspects of goal-directed behavior, providing insight into the neurochemical dysfunction that may underlie the inflexible and compulsive behaviors present in psychiatric disorders.
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