期刊
BIOLOGICAL PSYCHIATRY
卷 73, 期 1, 页码 24-31出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2012.06.023
关键词
Choline; magnetic resonance spectroscopy; N-acetylaspartate; glutamate; obsessive-compulsive disorder; OCD
资金
- National Institute of Mental Health [1K23-MH092397]
- David Judah Fund at Massachusetts General Hospital
- Transcept Pharmaceuticals
- Alkermes
- Shire Pharmaceuticals
Functional neuroimaging studies have converged to suggest that cortico-striatal-thalamo-cortical (CSTC) circuit dysfunction is a core pathophysiologic feature of obsessive-compulsive disorder (OCD). Now, complementary approaches examining regional neurochemistry are beginning to yield additional insights with regard to the neurobiology of aberrant CSTC circuitry in OCD. In particular, proton magnetic resonance spectroscopy, which allows for the in vivo quantification of various neurochemicals in the CSTC circuit and other brain regions, has recently been used extensively in studies of OCD patients. In this review, we summarize the diverse and often seemingly inconsistent findings of these studies, consider methodological factors that might help to explain these inconsistencies, and discuss several convergent findings that tentatively seem to be emerging. We conclude with suggestions for possible future proton magnetic resonance spectroscopy studies in OCD.
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