期刊
ANALYTICA CHIMICA ACTA
卷 898, 期 -, 页码 34-41出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2015.09.053
关键词
Layered doubled hydroxide nanohybrids; Manganese dioxide nanoparticles; Electrochemical biosensor; Hydrogen peroxide; Live cells
资金
- Shenzhen Strategic Emerging Industry Development Special Fund Project [JCYJ20130401144744190]
- Innovation Foundation of Huazhong University of Science and Technology Innovation Institute [2015ZZGH010, 2015TS150]
- Fundamental Research Funds for the Central Universities [2014QN110]
- National Natural Science Foundation of China [21305048]
We report a facile and green method for the fabrication of new type of electrocatalysts based on MnO2 nanoparticles incorporated on MgAl LDH P-type semiconductive channel and explore its practical applications as high-performance electrode materials for electrochemical biosensor. A series of MgAl layered doubled hydroxide (LDH) nanohybrids with fixed Mg/Al (M2+/M3+ atomic ratio of 3) and varied amount of MnCl2 center dot 4H(2)O are fabricated by a facile co-precipitation method. This approach demonstrates the combination of distinct properties including excellent intercalation features of LDH for entrapping nanoparticles and high loading of MnO2 nanoparticles in the host layers of LDH. Among all samples, Mn5-MgAl with 0.04% loaded manganese has a good crystalline morphology. A well-dispersed MnO2 nanoparticles encapsulated into the host matrix of hydrotalcite exhibit enhanced electrocatalytic activity towards the reduction of H2O2 as well as excellent stability, selectivity and reproducibility due to synergistic effect of good catalytic ability of MnO2 and conductive MgAl LDH. Glass carbon electrode (GCE) modified with Mn5-MgAl possesses a wide linear range of 0.05-78 mM, lowest detection limit 5 mu M (S/N = 3) and detection sensitivity of 0.9352 mu AmM-1. This outstanding performance enables it to be used for real-time tracking of H2O2 secreted by live HeLa cells. This work may provide new insight in clinical diagnosis, on-site environmental analysis and point of care testing devices. (C) 2015 Published by Elsevier B.V.
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