期刊
MOLECULAR MICROBIOLOGY
卷 37, 期 4, 页码 687-695出版社
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2958.2000.01972.x
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资金
- NIGMS NIH HHS [GM37048] Funding Source: Medline
In recent years, it has become clear that promoter recognition by bacterial RNA polymerase involves interactions not only between core promoter elements and the sigma subunit, but also between a DNA element upstream of the core promoter and the alpha subunit. DNA binding by alpha can increase transcription dramatically. Here we review the current state of our understanding of the alpha interaction with DNA during basal transcription initiation (i.e. in the absence of proteins other than RNA polymerase) and activated transcription initiation (i.e. when stimulated by transcription factors).
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