期刊
BIOLOGICAL PSYCHIATRY
卷 74, 期 7, 页码 482-489出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2013.04.030
关键词
Adolescence; gray matter volume; prenatal cocaine exposure; substance use initiation; voxel-based morphometry; whole brain
资金
- National Institutes of Health Office of Research on Women's Health (ORWH)
- National Institute of Drug Abuse's Specialized Centers of Research on Women's Health [P50DA016556]
- Boehringer Ingelheim
- Somaxon
- National Institutes of Health
- Veteran's Administration
- Mohegan Sun Casino
- National Center for Responsible Gaming
- Institute for Research on Gambling Disorders
- Forest Laboratories pharmaceuticals
Background: Studies of prenatal cocaine exposure have primarily examined childhood populations. Studying adolescents is especially important because adolescence is a time of changing motivations and initiation of substance use. Methods: Using magnetic resonance imaging and whole-brain voxel-based morphometry, we assessed gray matter volume (GMV) differences in 42 prenatally cocaine exposed (PCE) and 21 noncocaine-exposed (NCE) adolescents, aged 14 to 17 years. Associations between GMV differences in significant clusters and the probability of substance use initiation were examined. Results: PCE relative to NCE adolescents demonstrated three clusters of lower GMV involving a limbic and paralimbic (p < .001, family-wise error [FWE] corrected), superior frontal gyrus (p = .001, FWE corrected), and precuneus (p = .019, FWE corrected) cluster. GMVs in the superior frontal and precuneus clusters were associated with initiation of substance use. Each 1-mL decrease in GMV increased the probability of initiating substance use by 69.6% (p = .01) in the superior frontal cluster and 83.6% (p = .02) in the precuneus cluster. Conclusions: PCE is associated with structural differences in cortical and limbic regions. Lower GMVs in frontal cortical and posterior regions are associated with substance use initiation and may represent biological risk markers for substance use.
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