期刊
BIOLOGICAL PSYCHIATRY
卷 71, 期 9, 页码 767-773出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2011.08.020
关键词
Aging; gender; hostility; psychological stress; telomerase activity; telomere length
资金
- British Heart Foundation
- Medical Research Council, UK
- Bernard and Barbro Fund
- MRC [G0601647, G0902037] Funding Source: UKRI
- British Heart Foundation [RG/07/008/23674, RG/10/005/28296] Funding Source: researchfish
- Medical Research Council [G0601647, G8802774, G0100222, G19/35, G0902037] Funding Source: researchfish
Background: Hostility is associated with a significantly increased risk of age-related disease and mortality, yet the pathophysiological mechanisms involved remain unclear. Here we investigated the hypothesis that hostility might impact health by promoting cellular aging. Methods: We tested the relationship between cynical hostility and two known markers of cellular aging, leukocyte telomere length (TL) and leukocyte telomerase activity (TA), in 434 men and women from the Whitehall II cohort. Results: High-hostile men had significantly shorter leukocyte TL than their low-hostile counterparts. They also had elevated leukocyte TA, with a significantly increased likelihood of having both short TL and high TA, compared with low-hostile individuals. Conclusions: Because telomerase is known to counteract telomere shortening by synthesizing telomeric DNA repeats, particularly in the context of shortened telomeres, heightened TA might represent a compensatory response in high-hostile individuals. The relationship between hostility and disease is stronger in men than in women, and men generally have a shorter life expectancy than women. Our findings suggest that telomere attrition might represent a novel mechanism mediating the detrimental effects of hostility on men's health.
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