期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 97, 期 16, 页码 9093-9097出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.97.16.9093
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资金
- NICHD NIH HHS [HD-80841, F32 HD008041] Funding Source: Medline
- NIGMS NIH HHS [GM-49370, R01 GM049370] Funding Source: Medline
The dorsoventral axis of the Drosophila embryo is induced by a ventrally restricted ligand for the receptor Toll, The Toll ligand is generated by a proteolytic processing reaction, which occurs at the end of a proteolytic cascade and requires the gastrulation defective (gd), nudel, pipe, and windbeutel genes, Here we demonstrate that the GD protein is a serine protease and that the three other genes act to restrict GD activity to the ventral side of the embryo. Our data support a model in which the GD protease catalyzes the ventral activation of the proteolytic cascade that produces the Toll ligand.
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