期刊
BIOLOGICAL PSYCHIATRY
卷 72, 期 5, 页码 371-377出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2012.01.027
关键词
Amphetamine; carfentanil; dopamine; neuroimaging; opioids; PET; psychostimulants
资金
- GlaxoSmithKline (GSK)
- European College of Neuropsychopharmacology Research Grant for Young Scientists
- Wellcome Trust
- GSK
- European College of Neuropsychopharmacology
- Medical Research Council
- Pfizer
- Merck Sharp and Dohme
- Bristol Myers Squibb
- Esteve
- Novartis
- Asahi
- Organon
- Cypress
- Lilly
- Janssen
- Takeda
- Phamacia
- Therasci
- Passion for Life
- Hythiam
- Servier
- Roche
- Sanofi-Aventis
- Actelion
- Lundbeck
- Wyeth
- Reckitt-Benkiser
- Cephalon
- Merck Sharp
- Dohme
- Yamanouchi
- AZ
- P1vital
- MoD
- National Health Service
- Medical Research Council [G1002226, G0900897] Funding Source: researchfish
- MRC [G0900897, G1002226] Funding Source: UKRI
Background: We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [C-11] carfentanil binding with positron emission tomography (PET). Methods: Twelve healthy male volunteers underwent [C-11] carfentanil PET before and 3 hours after a single oral dose of d-amphetamine (either a high dose, .5 mg/kg, or a sub-pharmacological ultra-low dose, 1.25 mg total dose or approximately .017 mg/kg). Reductions in [C-11] carfentanil binding from baseline to post-amphetamine scans (Delta BPND) after the high and ultra-low amphetamine doses were assessed in 10 regions of interest. Results: [C-11] carfentanil binding was reduced after the high but not the ultra-low amphetamine dose in the frontal cortex, putamen, caudate, thalamus, anterior cingulate, and insula. Conclusions: Our findings indicate that oral amphetamine administration induces endogenous opioid release in different areas of human brain, including basal ganglia, frontal cortex areas, and thalamus. The combination of an amphetamine challenge and [C-11] carfentanil PET is a practical and robust method to probe the opioid system in the living human brain.
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