期刊
CHROMATOGRAPHIA
卷 52, 期 3-4, 页码 169-174出版社
SPRINGER HEIDELBERG
DOI: 10.1007/BF02490450
关键词
column liquid chromatography; on-, post- and pre-column derivation; amphetamine
The potential of different chromatographic systems for automated, on-line analysis of amphetamine in biological fluids is illustrated. The various systems integrate analyte purification and enrichment, separation, derivatization in different derivatization modes with o-phthaldialdehyde (OPA) and N-acetyl-L-cysteine (NAC), and fluorimetric detection. The reliability of the systems has been tested by analysing urine and plasma samples containing amphetamine in the 0.1 -20.0 mu g mL(-1) range. Pre, on and post-column derivatization strategies are compared in terms of their instrumental requirements, selectivity, sensitivity, linearity and reproducibility.
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