期刊
EXPERT OPINION ON INVESTIGATIONAL DRUGS
卷 9, 期 8, 页码 1777-1785出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543784.9.8.1777
关键词
HIV; human immunodeficiency virus type 1 integrase
资金
- NIGMS NIH HHS [GM 60153] Funding Source: Medline
Recently, a new class of oligonucleotides, forming G-quartet structures, has been developed as novel anti-HIV agents. Several critical structure-activity relationships between HIV-1 integrase and G-quartet oligonucleotides have been demonstrated. In addition the mechanism of the inhibition of HIV-I integrase by G-quartet oligonucleotides, such as T30695 and its derivatives, has been explored. This review summarises the preliminary studies of developing G-quartet oligonucleotides as novel anti-HIV agents in several aspects including structure-activity relationship, stability-activity correlation, mechanism of HIV-1 integrase inhibition, substitution of phosphorothioates and targeting HIV-1 integrase in infected cells, which, hopefully, could help for developing a novel, efficient anti-HIV agent.
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