期刊
BIOLOGICAL PSYCHIATRY
卷 69, 期 12, 页码 E113-E125出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2011.03.028
关键词
Cognitive control; dopamine (DA); functional magnetic resonance imaging (fMRI); prefrontal cortex; striatum; working memory
资金
- National Institutes of Health [MH63901, NS40813, DA02060, AG027984]
- Netherlands Organisation for Scientific Research
- Dutch Brain foundation
Brain dopamine (DA) has long been implicated in cognitive control processes, including working memory. However, the precise role of DA in cognition is not well-understood, partly because there is large variability in the response to dopaminergic drugs both across different behaviors and across different individuals. We review evidence from a series of studies with experimental animals, healthy humans, and patients with Parkinson's disease, which highlight two important factors that contribute to this large variability. First, the existence of an optimum DA level for cognitive function implicates the need to take into account baseline levels of DA when isolating the effects of DA. Second, cognitive control is a multifactorial phenomenon, requiring a dynamic balance between cognitive stability and cognitive flexibility. These distinct components might implicate the prefrontal cortex and the striatum, respectively. Manipulating DA will thus have paradoxical consequences for distinct cognitive control processes, depending on distinct basal or optimal levels of DA in different brain regions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据