Connecting vesicle transport to the cytoskeleton

The cytoskeleton is crucial for the efficient and polarized transport of vesicles in intracellular membrane-sorting pathways, Recent studies have identified specific kinesin, dynein, and myosin motor proteins that mediate defined membrane transport steps. Important clues have also been uncovered about the nature of motor-protein receptors on vesicular cargoes and the molecular mechanisms of motor protein regulation.