期刊
BIOLOGICAL PSYCHIATRY
卷 69, 期 1, 页码 55-62出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2010.08.016
关键词
Cognitive control; inhibition; response monitoring; saccades; schizophrenia; stop signal
资金
- National Alliance for Research on Schizophrenia and Depression
- E. Bronson Ingram Chair in Neuroscience
- [F31-MH085405-01]
- [MH073028]
- [P30-HD015052]
- [F32-EY016679]
- [FA9550-07-1-0192]
- [P30-EY08126]
- [MH055806]
- [MH073878]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P30HD015052] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [P30EY008126, F32EY016679] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH073878, R01MH073028, F31MH085405, R01MH055806] Funding Source: NIH RePORTER
Background: Cognitive control deficits are pervasive in individuals with schizophrenia (SZ) and are reliable predictors of functional outcome, but the specificity of these deficits and their underlying neural mechanisms have not been fully elucidated. The objective of the present study was to determine the nature of response inhibition and response monitoring deficits in SZ and their relationship to symptoms and social and occupational functioning with a behavioral paradigm that provides a translational approach to investigating cognitive control. Methods: Seventeen patients with SZ and 16 demographically matched healthy control subjects participated in a saccadic countermanding task. Performance on this task is approximated as a race between movement generation and inhibition processes; this race model provides an estimate of the time needed to cancel a planned movement. Response monitoring can be assessed by reaction time adjustments on the basis of trial history. Results: Saccadic reaction time was normal, but patients required more time to inhibit a planned saccade. The latency of the inhibitory process was associated with the severity of negative symptoms and poorer occupational functioning. Both groups slowed down significantly after correctly cancelled and erroneously noncancelled stop signal trials, but patients slowed down more than control subjects after correctly inhibited saccades. Conclusions: These results suggest that SZ is associated with a difficulty in inhibiting planned movements and an inflated response adjustment effect after inhibiting a saccade. Furthermore, behavioral results are consistent with potential abnormalities in frontal and supplementary eye fields in patients with SZ.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据