期刊
BIOLOGICAL PSYCHIATRY
卷 69, 期 2, 页码 146-156出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2010.03.029
关键词
Bipolar disorder; brain; DNA methylation; epigenetics; histone modification; postmortem; schizophrenia
资金
- Medical Research Council
- National Alliance for Research on Schizophrenic, and Depression
- Medical Research Council [G9817803B] Funding Source: researchfish
It has been widely speculated that epigenetic changes may play a role in the etiology of psychotic illnesses such as schizophrenia and bipolar disorder. Epigenetics is the study of mitotically heritable, but reversible, changes in gene expression that occur without a change in the genomic DNA sequence, brought about principally through alterations in DNA methylation and chromatin structure. Although numerous studies have examined psychosis-associated gene expression changes in postmortem brain samples, epigenetic studies of psychosis are in their infancy. In this article, we discuss methodologic and logistic issues related to epigenomic studies using postmortem brain tissue, before discussing the future implications of such research for our understanding of psychosis.
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