期刊
RADIOLOGY
卷 216, 期 2, 页码 555-558出版社
RADIOLOGICAL SOC NORTH AMER
DOI: 10.1148/radiology.216.2.r00au09555
关键词
breast; contrast media, complications; contrast media, effects; contrast media, toxicity; gadolinium; infants, newborn; magnetic resonance (MR), contrast media
PURPOSE: To analyze the amount of gadopentetate dimeglumine excreted into human breast milk following intravenous injection of a clinical dose. MATERIALS AND METHODS: Gadopentelate dimeglumine was injected intravenously in 20 lactating women (23-38 years of age). Breast-feeding was interrupted for at least 24 hours. Serial samples of expressed milk were collected and analyzed for gadolinium concentration by means of inductively coupled plasma atomic emission spectrometry at a wavelength of 342.247 nm. RESULTS: The cumulative amount of gadolinium excreted in human breast milk during 24 hours was 0.57 mu mol +/- 0.71 (SD range, 0.05-3.0 mu mol). the excreted dose was thus less than 0.04% of the administered intravenous dose (range, 0.001%-0.04%; mean, 0.009% +/- 0.010) for all cases. CONCLUSION: Less than 0.04% of administered gadopentetate dimeglumine is excreted into human breast milk. The amount transferred to a nursing infant orally would be far more than 100 times less than the permitted intravenous dose (200 mu mol per kilogram of body weight) for neonates. The recommendation of a 24-hour, suspension of breast-feeding for lactating women should thus be reconsidered.
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