期刊
BIOLOGICAL PSYCHIATRY
卷 69, 期 10, 页码 997-1005出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2010.12.036
关键词
Artificial neural network; delusions; derailment; memory; narrative language; prediction-error; schizophrenia
资金
- National Institute of Mental Health [R01MH066228]
- National Institutes of Health [R21-DC009446]
- National Science Foundation [EIA-0303609]
- Dana Foundation
- National Alliance for Research on Schizophrenia and Depression
- Department of Mental Health and Addiction Services of the State of Connecticut through Abraham Ribicoff Research Center at the Connecticut Mental Health Center
Background: Various malfunctions involving working memory, semantics, prediction error, and dopamine neuromodulation have been hypothesized to cause disorganized speech and delusions in schizophrenia. Computational models may provide insights into why some mechanisms are unlikely, suggest alternative mechanisms, and tie together explanations of seemingly disparate symptoms and experimental findings. Methods: Eight corresponding illness mechanisms were simulated in DISCERN, an artificial neural network model of narrative understanding and recall. For this study, DISCERN learned sets of autobiographical and impersonal crime stories with associated emotion coding. In addition, 20 healthy control subjects and 37 patients with schizophrenia or schizoaffective disorder matched for age, gender, and parental education were studied using a delayed story recall task. A goodness-of-fit analysis was performed to determine the mechanism best reproducing narrative breakdown profiles generated by healthy control subjects and patients with schizophrenia. Evidence of delusion-like narratives was sought in simulations best matching the narrative breakdown profile of patients. Results: All mechanisms were equivalent in matching the narrative breakdown profile of healthy control subjects. However, exaggerated prediction-error signaling during consolidation of episodic memories, termed hyperlearning, was statistically superior to other mechanisms in matching the narrative breakdown profile of patients. These simulations also systematically confused autobiographical agents with impersonal crime story agents to model fixed, self-referential delusions. Conclusions: Findings suggest that exaggerated prediction-error signaling in schizophrenia intermingles and corrupts narrative memories when incorporated into long-term storage, thereby disrupting narrative language and producing fixed delusional narratives. If further validated by clinical studies, these computational patients could provide a platform for developing and testing novel treatments.
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