Diheteropeptin, a novel substance with TGF-β-like activity, produced by a fungus, Diheterospora chlamydosporia II.: Physico-chemical properties and structure elucidation

The structure of diheteropeptin (1), a TGF-beta-like active substance from Diheterospora clamydosporia in Q58044, was determined to be a new cyclotetrapeptide, cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(2S,8R,9R)-2-amino-8,9-dihydroxydecanoyl-] by NMR, mass spectrometric and chemical studies.