期刊
BIOLOGICAL PSYCHIATRY
卷 66, 期 7, 页码 695-701出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2009.05.009
关键词
Anterior cingulotomy; autonomic nervous system; cingulate cortex; electrodermal activity; subcauclate tractotomy
资金
- Howard Hughes Medical Institute
- National Association for Research on Schizophrenia and Depression (NARSAD)
- CePhalon
- Cyheronics
- Medtronic
- Northstar Neuroscience
- Pfizer
- Forest
Background: In view of conflicting neuroimaging results regarding autonomic-specific activity within the anterior cingulate cortex (ACC), we investigated autonomic responses to direct brain stimulation during sterecitactic limbic surgery. Methods: Skin conductance activity and accelerative heart rate responses to multi-voltage stimulation of the ACC (n = 7) and paralimbic subcauclate (n = 5) regions were recorded during bilateral anterior cingulotomy and bilateral subcauclate tractotomy (in patients that had previously received an adequate lesion in the ACC), respectively. Results: Stimulations in both groups were accompanied by increased autonomic arousal. Skin conductance activity was significantly increased during ACC stimulations compared with paralimbic targets at 2 V (2.34 +/- .68 [score in microSiemens +/- SE] vs. .34 +/- .09, p = .013) and 3 V (3.52 +/- .86 vs. 1.12 +/- .37, p = .036), exhibiting a strong voltage-response relationship between stimulus magnitude and response amplitude (difference from 1 to 3 V = 1.15 +/- .90 vs. 3.52 +/- .86, p = .041). Heart rate response was less indicative of between-group differences. Conclusions: This is the first study of its kind aiming at seeking novel insights into the mechanisms responsible for central autonomic modulation. It supports a concept that interregional interactions account for the coordination of autonomic arousal.
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