期刊
BIOLOGICAL PSYCHIATRY
卷 65, 期 3, 页码 191-197出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2008.09.002
关键词
Amygdala; DNA methylation; epigenetic; fear conditioning; gene transcription; HDAC; hippocampus; histone; learning; LTP; memory
资金
- National Institutes of Health
- Evelyn F. McKnight Brain Research Foundation
- Rotary Clubs CART fund
- National Alliance for Research on Schizophrenia and Depression
This mini-review describes recent discoveries demonstrating that experience can drive the production of epigenetic marks in the adult nervous system and that the experience-dependent regulation of epigenetic molecular mechanisms in the mature central nervous system participates in the control of gene transcription underlying the formation of long-term memories. In the mammalian experimental systems investigated thus far, epigenetic mechanisms have been linked to associative fear conditioning, extinction of learned fear, and hippocampus-dependent spatial memory formation. Intriguingly, in one experimental system epigenetic marks at the level of chromatin structure (histone acetylation) have been linked to the recovery of memories that had seemed to be lost (i.e., not available for recollection). Environmental enrichment has long been known to have positive effects on memory capacity, and recent studies have suggested that these effects are at least partly due to the recruitment of epigenetic mechanisms by environmental enrichment. Finally, an uncoupling of signal transduction pathways from the regulation of epigenetic mechanisms in the nucleus has been implicated in the closure of developmental critical periods. Taken together, these eclectic findings suggest a new perspective on experience-dependent dynamic: regulation of epigenetic mechanisms in the adult nervous system and their relevance to biological psychiatry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据