期刊
BIOLOGICAL PSYCHIATRY
卷 63, 期 3, 页码 332-337出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2007.06.025
关键词
ADHD; anterior cingulate cortex; default-mode network; functional magnetic resonance imaging; precuneus; posterior cingulate cortex
资金
- NIDA NIH HHS [R01 DA016979-05, R01 DA016979] Funding Source: Medline
- NIMH NIH HHS [5T32MH067763, T32 MH067763-05, R01 MH083246, R21 MH066393, T32 MH067763, 5R21MH066393] Funding Source: Medline
Background: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed default-mode network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. Methods: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age-and sex-matched healthy volunteers. Results: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered atx = 8, y = 7,z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p <.0004, corrected). Secondary analyses revealed an extensive pattern of ADHD-related decreases in connectivity between precuneus and other default-mode network components, including ventromedial prefrontal cortex (p < 3 X 10(-11), corrected) and portions of posterior cingulate (p <.02, corrected). Conclusions: Together with prior unbiased anatomic evidence Of posterior volumetric abnormalities, our findings suggest that the long-range connections linking dorsal anterior cingulate to posterior cingulate and precuneus should be considered as a candidate locus of dysfunction in ADHD.
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