期刊
BIOLOGICAL PSYCHIATRY
卷 63, 期 3, 页码 293-300出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2007.05.014
关键词
decision-making; loss-chasing; motivation; pathological gambling; persistence; reward
资金
- Biotechnology and Biological Sciences Research Council [S20137] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [S20137] Funding Source: researchfish
Background: Continued gambling to recover previous losses (loss-chasing) is central to pathological gambling. However, very little is known about the neural mechanisms that mediate this behavior. Methods: We used functional magnetic resonance imaging (fMRI) to examine neural activity while healthy adult participants decided to chase losses or decided to quit gambling to prevent further losses. Results: Chasing losses was associated with increased activity in cortical areas linked to incentive-motivation and an expectation of reward. By contrast, quitting was associated with decreased activity in these areas but increased activity in areas associated with anxiety and conflict monitoring. Activity within the anterior cingulate cortex associated with the experience of chasing and then losing predicted decisions to stop chasing losses at the next opportunity. Conclusions: Excessive loss-chasing behavior in pathological gambling might involve a failure to appropriately balance activity within neural systems coding conflicting motivational states. Similar mechanisms might underlie the loss-of-control over appetitive behaviors in other impulse control disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据