期刊
JOURNAL OF IMMUNOLOGY
卷 165, 期 3, 页码 1612-1617出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.165.3.1612
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IL-10 is a unique cytokine because it is anti-inflammatory and immunosuppressive. IL-10 is regulated at the level of transcription, but the critical moths and the relevant transcription factors controlling this gene have remained elusive to date. We now report that a sequence at - 120 bp in the human IL-10 promoter binds Stat3 but no other Stat proteins. Mutation of this motif abrogates LPS-induced trans-activation. Overexpression of dominant negative Stat3 suppresses promoter activity, while wild-type Stall leads to an enhancement of this activity. Our results show that Stat3, by binding to a single motif in the IL-10 promoter, is controlling expression of the human IL-10 gene.
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