期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 10, 期 4, 页码 438-442出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(00)00112-3
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资金
- NHLBI NIH HHS [T32 HL07653] Funding Source: Medline
- NIGMS NIH HHS [R01 GM47485] Funding Source: Medline
Protein misfolding is increasingly recognized as a factor in many diseases, including cystic fibrosis, Parkinson's, Alzheimer's and atherosclerosis. Many proteins involved in misfolding-based pathologies are membrane-associated, such that the bilayer may play roles in normal and aberrant folding. It can be argued that the in vivo partitioning of eukaryotic membrane proteins between folding and misfolding pathways is under kinetic control. Moreover, the balance between these pathways can be surprisingly delicate.
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